Version 5.4
Homo sapiens Gene: TBKBP1
Summary
InnateDB Gene IDBG-56118.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBKBP1
Gene Name TBK1 binding protein 1
Synonyms ProSAPiP2; SINTBAD
Species Homo sapiens
Ensembl Gene ENSG00000198933
Encoded Proteins
IDBP-56120
TBK1 binding protein 1
IDBP-587812
TBK1 binding protein 1
IDBP-759261
IDBP-810041
TBK1 binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17568778
A novel component of innate antiviral immunity, it shares a TBK1-binding domain with AZI2 and TANK
Entrez Gene
Summary TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47694081-47712050
Strand Forward strand
Band q21.32
Transcripts
ENST00000361722 ENSP00000354777
ENST00000537587 ENSP00000446365
ENST00000578982 ENSP00000462339
ENST00000622396 ENSP00000484395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038517
View Gene Order
ENSBTAG00000011280
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_014726 XM_005257859 XM_005257860 XM_005257861 XM_005257862 XM_006722199
HUGO
OMIM
CCDS CCDS45722
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca