Homo sapiens Gene: MRPL10
Summary
InnateDB Gene IDBG-56250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL10
Gene Name mitochondrial ribosomal protein L10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159111
Encoded Proteins
mitochondrial ribosomal protein L10
mitochondrial ribosomal protein L10
mitochondrial ribosomal protein L10
mitochondrial ribosomal protein L10
mitochondrial ribosomal protein L10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47823272-47831534
Strand Reverse strand
Band q21.32
Transcripts
ENST00000351111 ENSP00000324100
ENST00000290208 ENSP00000290208
ENST00000414011 ENSP00000395870
ENST00000421763 ENSP00000404039
ENST00000423147 ENSP00000390624
ENST00000466016
ENST00000480901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005762 mitochondrial large ribosomal subunit
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.347535
RefSeq NM_145255 NM_148887
HUGO
OMIM
CCDS CCDS11516 CCDS11517
HPRD 14738
IMGT
EMBL
GenPept
RNA Seq Atlas