Version 5.4
Homo sapiens Gene: DCLRE1C
Summary
InnateDB Gene IDBG-56338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCLRE1C
Gene Name DNA cross-link repair 1C
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152457
Encoded Proteins
IDBP-56340
DNA cross-link repair 1C
IDBP-56342
DNA cross-link repair 1C
IDBP-56346
DNA cross-link repair 1C
IDBP-56348
DNA cross-link repair 1C
IDBP-56350
DNA cross-link repair 1C
IDBP-56352
DNA cross-link repair 1C
IDBP-56354
DNA cross-link repair 1C
IDBP-56356
DNA cross-link repair 1C
IDBP-56358
DNA cross-link repair 1C
IDBP-56360
DNA cross-link repair 1C
IDBP-236665
DNA cross-link repair 1C
IDBP-367100
DNA cross-link repair 1C
IDBP-367103
DNA cross-link repair 1C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:14897359-14954432
Strand Reverse strand
Band p13
Transcripts
ENST00000378289 ENSP00000367538
ENST00000378278 ENSP00000367527
ENST00000357717 ENSP00000350349
ENST00000378258 ENSP00000367506
ENST00000378255 ENSP00000367503
ENST00000378246 ENSP00000367492
ENST00000378254 ENSP00000367502
ENST00000378249 ENSP00000367496
ENST00000378242 ENSP00000367488
ENST00000378241 ENSP00000367487
ENST00000396817 ENSP00000380030
ENST00000418843 ENSP00000391428
ENST00000456122 ENSP00000413180
ENST00000492201
ENST00000489845
ENST00000489161
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 17 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016787 hydrolase activity
Biological Process
GO:0000723 telomere maintenance
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0008152 metabolic process
GO:0010212 response to ionizing radiation
GO:0030183 B cell differentiation
GO:0051276 chromosome organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026648
View Gene Order
ENSBTAG00000010220
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03450
Non-homologous end-joining pathway
hsa05340
Primary immunodeficiency pathway
INOH
PID NCI
atm_pathway
ATM pathway
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt Q96SD1
TrEMBL B3KSJ7 X6R9W9 X6RCQ3 X6RJV5
UniProt Splice Variant
Entrez Gene 64421
UniGene Hs.656065 Hs.737284
RefSeq NM_001033855 NM_001033857 NM_001033858 NM_001289076 NM_001289077 NM_001289078 NM_001289079 NM_022487 XM_005252558
HUGO HGNC:17642
OMIM 605988
CCDS CCDS31149 CCDS31150 CCDS7105
HPRD
IMGT
EMBL AC069544 AF395747 AF395748 AF395749 AF395750 AF395751 AF395752 AJ296101 AK021422 AK093757 AL360083 BC000863 BC009185 BC022254 CH471072 DQ504427
GenPept AAH00863 AAH09185 AAH22254 AAM53255 AAM53256 AAM53257 AAM53258 AAM53259 AAM53260 ABF47101 BAB13820 BAG52759 CAC37570 CAI40018 CAI40019 CAI40020 CAI40021 CAI40022 CAI40023 CAI40024 CAI40025 EAW86248 EAW86250 EAW86251
RNA Seq Atlas 64421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca