InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCT7

Summary

InnateDB Gene

IDBG-56424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCT7

Gene Name

chaperonin containing TCP1, subunit 7 (eta)

Synonyms

CCTETA; CCTH; NIP7-1; TCP1ETA

Species

Homo sapiens

Ensembl Gene

ENSG00000135624

Encoded Proteins

IDBP-56426

chaperonin containing TCP1, subunit 7 (eta)

IDBP-380022

chaperonin containing TCP1, subunit 7 (eta)

IDBP-233027

chaperonin containing TCP1, subunit 7 (eta)

IDBP-295568

chaperonin containing TCP1, subunit 7 (eta)

IDBP-601979

chaperonin containing TCP1, subunit 7 (eta)

IDBP-603400

chaperonin containing TCP1, subunit 7 (eta)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:73233420-73253021

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000258091	ENSP00000258091
ENST00000399032	ENSP00000412996
ENST00000398422	ENSP00000381456
ENST00000409924	ENSP00000386978
ENST00000471927
ENST00000469844
ENST00000473197
ENST00000492253
ENST00000461290
ENST00000464397
ENST00000480489
ENST00000473786
ENST00000482064
ENST00000488856
ENST00000540468	ENSP00000442058
ENST00000539919	ENSP00000437824

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	114 [view]
Protein-Protein	111 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome