Version 5.4
Homo sapiens Gene: GIT2
Summary
InnateDB Gene IDBG-56520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIT2
Gene Name G protein-coupled receptor kinase interacting ArfGAP 2
Synonyms CAT-2; CAT2
Species Homo sapiens
Ensembl Gene ENSG00000139436
Encoded Proteins
IDBP-56524
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-56526
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-56530
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-56540
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-383093
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-588425
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-597835
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-810835
G protein-coupled receptor kinase interacting ArfGAP 2
IDBP-590798
G protein-coupled receptor kinase interacting ArfGAP 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:109929792-109996389
Strand Reverse strand
Band q24.11
Transcripts
ENST00000355312 ENSP00000347464
ENST00000361006 ENSP00000354282
ENST00000354574 ENSP00000346585
ENST00000320063 ENSP00000323833
ENST00000457474 ENSP00000391813
ENST00000553118 ENSP00000447465
ENST00000551209 ENSP00000448832
ENST00000552978
ENST00000550186 ENSP00000473637
ENST00000546613
ENST00000548000
ENST00000548655
ENST00000549999
ENST00000550480
ENST00000547815 ENSP00000450348
ENST00000551455
ENST00000547694
ENST00000551721
ENST00000548643
ENST00000547267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0048266 behavioral response to pain
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041890
View Gene Order
ENSBTAG00000006506
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.434996 Hs.686678
RefSeq NM_001135213 NM_001135214 NM_014776 NM_057169 NM_057170 NM_139201 XM_005253997 XM_006719714
HUGO
OMIM
CCDS CCDS44968 CCDS44969 CCDS55884 CCDS9138 CCDS9139
HPRD 09779
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca