InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CBLC

Summary

InnateDB Gene

IDBG-56595.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBLC

Gene Name

Cbl proto-oncogene, E3 ubiquitin protein ligase C

Synonyms

CBL-3; CBL-SL; RNF57

Species

Homo sapiens

Ensembl Gene

ENSG00000142273

Encoded Proteins

IDBP-56597

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

IDBP-56599

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44777869-44800634

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000270279	ENSP00000270279
ENST00000341505	ENSP00000340250

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0017124	SH3 domain binding
GO:0046872	metal ion binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043407	negative regulation of MAP kinase activity

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040525

View Gene Order

ENSBTAG00000009494

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

hsa04012

ErbB signaling pathway pathway

hsa04120

Ubiquitin mediated proteolysis pathway

hsa04910

Insulin signaling pathway pathway

hsa04660

T cell receptor signaling pathway pathway

hsa04630

Jak-STAT signaling pathway pathway

hsa05220

Chronic myeloid leukemia pathway

hsa04144

Endocytosis pathway

hsa05200

Pathways in cancer pathway

hsa05100

Bacterial invasion of epithelial cells pathway

INOH

INOH website

GPCR Adenosine A2A receptor signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

Q9ULV8

TrEMBL

UniProt Splice Variant

Entrez Gene

23624

UniGene

Hs.466907

RefSeq

NM_001130852 NM_012116 XM_005258696

HUGO

HGNC:15961

OMIM

608453

CCDS

CCDS12643 CCDS46109

HPRD

IMGT

EMBL

AB028645 AF117646 AF117647 BC028915

GenPept

AAD34341 AAD34342 AAH28915 BAA86298

RNA Seq Atlas

23624