InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CBX1

Summary

InnateDB Gene

IDBG-56608.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBX1

Gene Name

chromobox homolog 1

Synonyms

CBX; HP1-BETA; HP1Hs-beta; HP1Hsbeta; M31; MOD1; p25beta

Species

Homo sapiens

Ensembl Gene

ENSG00000108468

Encoded Proteins

IDBP-56610

chromobox homolog 1

IDBP-243678

chromobox homolog 1

IDBP-294640

chromobox homolog 1

IDBP-380498

chromobox homolog 1

IDBP-758849

IDBP-757777

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:48070052-48101521

Strand

Reverse strand

Band

q21.32

Transcripts

ENST00000225603	ENSP00000225603
ENST00000393408	ENSP00000377060
ENST00000402583	ENSP00000385413
ENST00000444685	ENSP00000393179
ENST00000495350	ENSP00000465985
ENST00000581003	ENSP00000462242

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	83 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:1990226	histone methyltransferase binding

Biological Process

GO:0045892

negative regulation of transcription, DNA-templated

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0001939	female pronucleus
GO:0001940	male pronucleus
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005720	nuclear heterochromatin
GO:0005721	centromeric heterochromatin
GO:0005819	spindle
GO:0010369	chromocenter

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018666

View Gene Order

ENSBTAG00000002949

Not yet available

Cross-References

SwissProt

P83916

TrEMBL

B5MD17 C9JWS9 J3KS05 K7ELA4 Q6IBN6

UniProt Splice Variant

Entrez Gene

10951

UniGene

Hs.712805 Hs.77254

RefSeq

NM_001127228 NM_006807

HUGO

HGNC:1551

OMIM

604511

CCDS

CCDS11525

HPRD

IMGT

EMBL

AC004477 AC006468 AK312615 BC002609 BC021302 CH471109 CR456766 U35451

GenPept

AAB81548 AAH02609 AAH21302 BAG35502 CAG33047 EAW94758 EAW94759 EAW94760 EAW94761

RNA Seq Atlas

10951