InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP2A2

Summary

InnateDB Gene

IDBG-56943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2A2

Gene Name

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Synonyms

ATP2B; DAR; DD; SERCA2

Species

Homo sapiens

Ensembl Gene

ENSG00000174437

Encoded Proteins

IDBP-56945

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

IDBP-56947

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

IDBP-598593

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

IDBP-588695

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

IDBP-596997

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

IDBP-591596

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:110280756-110351093

Strand

Forward strand

Band

q24.11

Transcripts

ENST00000308664	ENSP00000311186
ENST00000377685	ENSP00000366913
ENST00000313432
ENST00000552636	ENSP00000447406
ENST00000539276	ENSP00000440045
ENST00000548169	ENSP00000449454
ENST00000550248
ENST00000547050
ENST00000549840
ENST00000550262
ENST00000547792
ENST00000553144	ENSP00000450407

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0019829	cation-transporting ATPase activity
GO:0019899	enzyme binding
GO:0044548	S100 protein binding
GO:0046872	metal ion binding
GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006984	ER-nucleus signaling pathway
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0008544	epidermis development
GO:0010460	positive regulation of heart rate
GO:0034220	ion transmembrane transport
GO:0045822	negative regulation of heart contraction
GO:0055085	transmembrane transport
GO:0055119	relaxation of cardiac muscle
GO:0070296	sarcoplasmic reticulum calcium ion transport
GO:0070588	calcium ion transmembrane transport
GO:0086036	regulation of cardiac muscle cell membrane potential

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031095	platelet dense tubular network membrane
GO:0033017	sarcoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle