Version 5.4
Homo sapiens Gene: RELB
Summary
InnateDB Gene IDBG-57021.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RELB
Gene Name v-rel reticuloendotheliosis viral oncogene homolog B
Synonyms I-REL; IREL; REL-B
Species Homo sapiens
Ensembl Gene ENSG00000104856
Encoded Proteins
IDBP-57023
v-rel reticuloendotheliosis viral oncogene homolog B
IDBP-474825
v-rel reticuloendotheliosis viral oncogene homolog B
IDBP-483043
v-rel reticuloendotheliosis viral oncogene homolog B
IDBP-761346
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16951372
RELB is a NF-kappaB subunit that participates in endotoxin tolerance by repressing pro-inflammatory gene expression.
PMID 17823304
RELB mediates transcription of chemokines like IL8 via activation of AHR and Protein kinase A, and its expression is inhibited by Vitamin D3 analog in DCs.
PMID 12657634
RELB acts as both transcription factor as well as a repressor of NF-kappaB gene expression by forming heterodimers with NFKB1 (p50 subunit) and NFKB2 (p100 subunit) or inhibiting RELA DNA binding activity, respectively.
PMID 19020113
RELB sustains NFKBIA (IkappaB alpha) expression during endotoxin tolerance, RelB transcription activation requires binding to the (IkappaB alpha) proximal promoter along with NFKB1 (p50), and is associated with an apparent dimer exchange with RELA (p65).
PMID 19020113
RELB functions as a dual transcription regulator during LPS tolerance and human severe systemic inflammation (SSI) by activating and repressing innate immunity genes.
PMID 21419662
RELB is required for IL17A production in T cell in response to bacterial infection. RELB deficient T cells resulted in a diminished innate immune response to E. coli infection. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21419662
[Mus musculus] Relb is required for Il17a production in T cell in response to bacterial infection. Relb deficient T cells resulted in a diminished innate immune response to E. coli infection.
PMID 25367573
[Mus musculus] Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45001430-45038194
Strand Forward strand
Band q13.32
Transcripts
ENST00000221452 ENSP00000221452
ENST00000505236 ENSP00000423287
ENST00000509480 ENSP00000427348
ENST00000510184
ENST00000509229
ENST00000589972 ENSP00000468460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 104 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 104 [view]
Protein-Protein 67 [view]
Protein-DNA 36 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0019882 antigen processing and presentation
GO:0032922 circadian regulation of gene expression
GO:0038061 NIK/NF-kappaB signaling
GO:0042088 T-helper 1 type immune response
GO:0043011 myeloid dendritic cell differentiation
GO:0045063 T-helper 1 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0071470 cellular response to osmotic stress
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002983
View Gene Order
ENSBTAG00000038428
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_24
TSLP pathway
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
nfkappabalternativepathway
Alternative NF-kappaB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654402
RefSeq NM_006509 XM_005259127
HUGO
OMIM
CCDS CCDS46110
HPRD 06886
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca