Homo sapiens Gene: CHMP5
Summary
InnateDB Gene IDBG-57079.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP5
Gene Name charged multivesicular body protein 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000086065
Encoded Proteins
charged multivesicular body protein 5
charged multivesicular body protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:33264879-33282069
Strand Forward strand
Band p13.3
Transcripts
ENST00000223500 ENSP00000223500
ENST00000419016 ENSP00000442725
ENST00000487080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001919 regulation of receptor recycling
GO:0007034 vacuolar transport
GO:0007040 lysosome organization
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
HIV Life Cycle pathway
HIV Infection pathway
Budding and maturation of HIV virion pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NZZ3
TrEMBL
UniProt Splice Variant
Entrez Gene 51510
UniGene Hs.635313
RefSeq NM_016410 NM_001195536
HUGO HGNC:26942
OMIM 610900
CCDS CCDS6537 CCDS56569
HPRD 15408
IMGT
EMBL AF132968 AF161525 AF229832 AF275810 AK295744 AK315455 AL356472 BC006974 BC007457 BC016698 BC020796 BC021168 CH471071
GenPept AAD27743 AAF29140 AAF42917 AAG23821 AAH06974 AAH07457 AAH16698 AAH20796 AAH21168 BAG37842 BAG58578 CAH72744 EAW58512
RNA Seq Atlas 51510