Version 5.4
Homo sapiens Gene: LTBP3
Summary
InnateDB Gene IDBG-57140.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTBP3
Gene Name latent transforming growth factor beta binding protein 3
Synonyms LTBP-3; LTBP2; pp6425; STHAG6
Species Homo sapiens
Ensembl Gene ENSG00000168056
Encoded Proteins
IDBP-57142
latent transforming growth factor beta binding protein 3
IDBP-57144
latent transforming growth factor beta binding protein 3
IDBP-595041
latent transforming growth factor beta binding protein 3
IDBP-597453
latent transforming growth factor beta binding protein 3
IDBP-591447
latent transforming growth factor beta binding protein 3
IDBP-587821
latent transforming growth factor beta binding protein 3
IDBP-585973
latent transforming growth factor beta binding protein 3
IDBP-596506
latent transforming growth factor beta binding protein 3
IDBP-597841
latent transforming growth factor beta binding protein 3
IDBP-584335
latent transforming growth factor beta binding protein 3
IDBP-589632
latent transforming growth factor beta binding protein 3
IDBP-590698
latent transforming growth factor beta binding protein 3
IDBP-597366
latent transforming growth factor beta binding protein 3
IDBP-600468
latent transforming growth factor beta binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65538560-65558930
Strand Reverse strand
Band q13.1
Transcripts
ENST00000301873 ENSP00000301873
ENST00000322147 ENSP00000326647
ENST00000529582
ENST00000530785 ENSP00000434315
ENST00000529189 ENSP00000434406
ENST00000532932 ENSP00000435530
ENST00000528516 ENSP00000432350
ENST00000526927 ENSP00000431219
ENST00000532661 ENSP00000436341
ENST00000529371 ENSP00000436032
ENST00000530866 ENSP00000435276
ENST00000526124
ENST00000530990
ENST00000525443
ENST00000527339 ENSP00000432121
ENST00000528966
ENST00000529764
ENST00000527792
ENST00000526825 ENSP00000435146
ENST00000530426 ENSP00000432476
ENST00000524798
ENST00000536982 ENSP00000441912
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001501 skeletal system development
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0030198 extracellular matrix organization
GO:0030502 negative regulation of bone mineralization
GO:0032331 negative regulation of chondrocyte differentiation
GO:0036363 transforming growth factor beta activation
GO:0045780 positive regulation of bone resorption
GO:0046849 bone remodeling
GO:0060349 bone morphogenesis
GO:0060430 lung saccule development
GO:1902462 positive regulation of mesenchymal stem cell proliferation
GO:2000741 positive regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024940
View Gene Order
ENSBTAG00000006747
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PPT7 E9PQR0 E9PR75
UniProt Splice Variant
Entrez Gene 4054
UniGene Hs.289019
RefSeq NM_001130144 NM_001164266 NM_021070
HUGO HGNC:6716
OMIM 602090
CCDS CCDS44647 CCDS8103
HPRD 03649
IMGT
EMBL AP000769 AP001362
GenPept
RNA Seq Atlas 4054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca