InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP1CC

Summary

InnateDB Gene

IDBG-57303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1CC

Gene Name

protein phosphatase 1, catalytic subunit, gamma isozyme

Synonyms

PP-1G; PP1C; PPP1G

Species

Homo sapiens

Ensembl Gene

ENSG00000186298

Encoded Proteins

IDBP-57305

protein phosphatase 1, catalytic subunit, gamma isozyme

IDBP-57307

protein phosphatase 1, catalytic subunit, gamma isozyme

IDBP-599553

protein phosphatase 1, catalytic subunit, gamma isozyme

IDBP-595264

protein phosphatase 1, catalytic subunit, gamma isozyme

IDBP-588058

protein phosphatase 1, catalytic subunit, gamma isozyme

IDBP-584873

protein phosphatase 1, catalytic subunit, gamma isozyme

IDBP-595349

protein phosphatase 1, catalytic subunit, gamma isozyme

IDBP-809484

protein phosphatase 1, catalytic subunit, gamma isozyme

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23499489

PPP1CC dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.

InnateDB Annotation from Orthologs

Summary

PMID 23499489

[Mus musculus] PPP1CC dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.

Entrez Gene

Summary

The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:110719680-110742939

Strand

Reverse strand

Band

q24.11

Transcripts

ENST00000335007	ENSP00000335084
ENST00000340766	ENSP00000341779
ENST00000550261	ENSP00000447528
ENST00000546904
ENST00000551582	ENSP00000447090
ENST00000553024
ENST00000546933	ENSP00000447122
ENST00000550991	ENSP00000448981
ENST00000551676	ENSP00000448437
ENST00000551690
ENST00000620030	ENSP00000482210

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	239 [view]
Protein-Protein	237 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005977	glycogen metabolic process
GO:0006470	protein dephosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0019433	triglyceride catabolic process
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051301	cell division

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016607	nuclear speck
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0043234	protein complex
GO:0070688	MLL5-L complex
GO:0072357	PTW/PP1 phosphatase complex