InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MGAT2

Summary

InnateDB Gene

IDBG-5731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGAT2

Gene Name

mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Synonyms

CDG2A; CDGS2; GLCNACTII; GNT-II; GNT2

Species

Homo sapiens

Ensembl Gene

ENSG00000168282

Encoded Proteins

IDBP-5733

mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5\' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:49620795-49623481

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000305386

ENSP00000307423

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0030246	carbohydrate binding

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0009311	oligosaccharide metabolic process
GO:0009312	oligosaccharide biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043998

View Gene Order

ENSBTAG00000033891

Not yet available

Pathways

NETPATH

REACTOME

REACT_25302

Reactions specific to the complex N-glycan synthesis pathway pathway

REACT_25046

Transport to the Golgi and subsequent modification pathway

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_22161

Post-translational protein modification pathway

REACT_25208

N-glycan antennae elongation in the medial/trans-Golgi pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

Q10469

TrEMBL

B4DDK9

UniProt Splice Variant

Entrez Gene

4247

UniGene

Hs.93338

RefSeq

NM_002408

HUGO

HGNC:7045

OMIM

602616

CCDS

CCDS9690

HPRD

IMGT

EMBL

AK056167 AK075199 AK293231 BC006390 CH471078 U15128

GenPept

AAA86956 AAH06390 BAG51637 BAG52082 BAG56770 EAW65758

RNA Seq Atlas

4247