Homo sapiens Gene: MGAT2
Summary
InnateDB Gene IDBG-5731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGAT2
Gene Name mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Synonyms CDG2A; CDGS2; GLCNACTII; GNT-II; GNT2;
Species Homo sapiens
Ensembl Gene ENSG00000168282
Encoded Proteins
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5\' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:49620795-49623481
Strand Forward strand
Band q21.3
Transcripts
ENST00000305386 ENSP00000307423
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0009311 oligosaccharide metabolic process
GO:0009312 oligosaccharide biosynthetic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Reactions specific to the complex N-glycan synthesis pathway pathway
Transport to the Golgi and subsequent modification pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q10469
TrEMBL B4DDK9
UniProt Splice Variant
Entrez Gene 4247
UniGene Hs.93338
RefSeq NM_002408
HUGO HGNC:7045
OMIM 602616
CCDS CCDS9690
HPRD
IMGT
EMBL AK056167 AK075199 AK293231 BC006390 CH471078 U15128
GenPept AAA86956 AAH06390 BAG51637 BAG52082 BAG56770 EAW65758
RNA Seq Atlas 4247