InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RIPK1

Summary

InnateDB Gene

IDBG-57326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RIPK1

Gene Name

receptor (TNFRSF)-interacting serine-threonine kinase 1

Synonyms

RIP; RIP1

Species

Homo sapiens

Ensembl Gene

ENSG00000137275

Encoded Proteins

IDBP-57328

receptor (TNFRSF)-interacting serine-threonine kinase 1

IDBP-57330

receptor (TNFRSF)-interacting serine-threonine kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16543241

RIPK1 ubiquitination on Lys377 is required for tumour necrosis factor (TNF-alpha) induced NF-kappaB activation.

PMID 16825191

RIPK1 is a death domain kinase that is one of the critical components involved in mediating DNA damage-induced, p53-independent cell death.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:3063991-3115187

Strand

Forward strand

Band

p25.2

Transcripts

ENST00000380409	ENSP00000369773
ENST00000259808	ENSP00000259808
ENST00000479389

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 148 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	148 [view]
Protein-Protein	148 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0070513	death domain binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0007257	activation of JUN kinase activity
GO:0010942	positive regulation of cell death
GO:0032481	positive regulation of type I interferon production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034612	response to tumor necrosis factor
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0036289	peptidyl-serine autophosphorylation
GO:0042327	positive regulation of phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043068	positive regulation of programmed cell death
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade
GO:0044257	cellular protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045651	positive regulation of macrophage differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0051347	positive regulation of transferase activity
GO:0060545	positive regulation of necroptotic process
GO:0070231	T cell apoptotic process
GO:0070266	necroptotic process
GO:0070926	regulation of ATP:ADP antiporter activity
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097343	ripoptosome assembly
GO:0097527	necroptotic signaling pathway
GO:1901026	ripoptosome assembly involved in necroptotic process
GO:1990000	amyloid fibril formation
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0031264	death-inducing signaling complex
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0097342	ripoptosome