Homo sapiens Gene: GIP
Summary
InnateDB Gene IDBG-57393.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIP
Gene Name gastric inhibitory polypeptide
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159224
Encoded Proteins
gastric inhibitory polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48958554-48968596
Strand Reverse strand
Band q21.32
Transcripts
ENST00000357424 ENSP00000350005
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
Biological Process
GO:0001101 response to acid
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007613 memory
GO:0008344 adult locomotory behavior
GO:0009743 response to carbohydrate
GO:0009749 response to glucose
GO:0010269 response to selenium ion
GO:0010828 positive regulation of glucose transport
GO:0014070 response to organic cyclic compound
GO:0019233 sensory perception of pain
GO:0031018 endocrine pancreas development
GO:0031667 response to nutrient levels
GO:0032024 positive regulation of insulin secretion
GO:0033993 response to lipid
GO:0035640 exploration behavior
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0044267 cellular protein metabolic process
GO:0048678 response to axon injury
GO:0050796 regulation of insulin secretion
GO:0050806 positive regulation of synaptic transmission
GO:0055123 digestive system development
GO:0060291 long-term synaptic potentiation
GO:0070094 positive regulation of glucagon secretion
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0034774 secretory granule lumen
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Incretin synthesis, secretion, and inactivation pathway
Glucagon-type ligand receptors pathway
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
Metabolism of proteins pathway
GPCR ligand binding pathway
Peptide hormone metabolism pathway
Class B/2 (Secretin family receptors) pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P09681
TrEMBL
UniProt Splice Variant
Entrez Gene 2695
UniGene Hs.1454
RefSeq NM_004123
HUGO HGNC:4270
OMIM 137240
CCDS CCDS11542
HPRD
IMGT
EMBL BC069100 BC069663 BC069686 BC069746 BC096146 BC096147 BC096148 BC096149 M18185 M31675 M31676 M31677 M31678 M31679
GenPept AAA53192 AAA88043 AAH69100 AAH69663 AAH69686 AAH69746 AAH96146 AAH96147 AAH96148 AAH96149
RNA Seq Atlas 2695