Version 5.4
Homo sapiens Gene: PPP1R13L
Summary
InnateDB Gene IDBG-57434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R13L
Gene Name protein phosphatase 1, regulatory subunit 13 like
Synonyms IASPP; NKIP1; RAI; RAI4
Species Homo sapiens
Ensembl Gene ENSG00000104881
Encoded Proteins
IDBP-57436
protein phosphatase 1, regulatory subunit 13 like
IDBP-381910
protein phosphatase 1, regulatory subunit 13 like
IDBP-763934
IDBP-761463
IDBP-759995
IDBP-762985
IDBP-807383
protein phosphatase 1, regulatory subunit 13 like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45379634-45406349
Strand Reverse strand
Band q13.32
Transcripts
ENST00000360957 ENSP00000354218
ENST00000418234 ENSP00000403902
ENST00000587270
ENST00000589858
ENST00000589371 ENSP00000466555
ENST00000592134 ENSP00000467471
ENST00000585905
ENST00000593226 ENSP00000466730
ENST00000591986 ENSP00000466939
ENST00000612351 ENSP00000478646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042802 identical protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003215 cardiac right ventricle morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0009791 post-embryonic development
GO:0031076 embryonic camera-type eye development
GO:0035264 multicellular organism growth
GO:0042633 hair cycle
GO:0048871 multicellular organismal homeostasis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030054 cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040734
View Gene Order
ENSBTAG00000020689
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466937
RefSeq NM_001142502 NM_006663 XM_005258424
HUGO
OMIM
CCDS CCDS33050
HPRD 09195
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca