Version 5.4
Homo sapiens Gene: STK10
Summary
InnateDB Gene IDBG-57659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK10
Gene Name serine/threonine kinase 10
Synonyms LOK; PRO2729
Species Homo sapiens
Ensembl Gene ENSG00000072786
Encoded Proteins
IDBP-57661
serine/threonine kinase 10
IDBP-482584
serine/threonine kinase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:172042073-172188386
Strand Reverse strand
Band q35.1
Transcripts
ENST00000176763 ENSP00000176763
ENST00000517360
ENST00000520476 ENSP00000428806
ENST00000523615
ENST00000519269
ENST00000523603
ENST00000522879
ENST00000517775
ENST00000517524
ENST00000517527
ENST00000522936
ENST00000519710
ENST00000521322
ENST00000518267
ENST00000519441
ENST00000517381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042801 polo kinase kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0023014 signal transduction by phosphorylation
GO:0046777 protein autophosphorylation
GO:0071593 lymphocyte aggregation
GO:2000401 regulation of lymphocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020272
View Gene Order
ENSBTAG00000017457
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.519756 Hs.625853
RefSeq NM_005990
HUGO
OMIM
CCDS CCDS34290
HPRD 06796
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca