Version 5.4
Homo sapiens Gene: ERP29
Summary
InnateDB Gene IDBG-57857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERP29
Gene Name endoplasmic reticulum protein 29
Synonyms C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB; PDIA9
Species Homo sapiens
Ensembl Gene ENSG00000089248
Encoded Proteins
IDBP-57859
endoplasmic reticulum protein 29
IDBP-383462
endoplasmic reticulum protein 29
IDBP-596853
endoplasmic reticulum protein 29
IDBP-590788
endoplasmic reticulum protein 29
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112013316-112023451
Strand Forward strand
Band q24.13
Transcripts
ENST00000261735 ENSP00000261735
ENST00000455836 ENSP00000412083
ENST00000553161
ENST00000552052 ENSP00000447472
ENST00000546477 ENSP00000449018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0006886 intracellular protein transport
GO:0009306 protein secretion
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0009986 cell surface
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029616
View Gene Order
ENSBTAG00000006665
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.714226 Hs.75841
RefSeq NM_001034025 NM_006817
HUGO
OMIM
CCDS CCDS44977 CCDS9158
HPRD 03794
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca