Homo sapiens Gene: CTSW
Summary
InnateDB Gene IDBG-57946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSW
Gene Name cathepsin W
Synonyms LYPN;
Species Homo sapiens
Ensembl Gene ENSG00000172543
Encoded Proteins
cathepsin W
cathepsin W
cathepsin W
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65879809-65883741
Strand Forward strand
Band q13.1
Transcripts
ENST00000307886 ENSP00000311300
ENST00000524681
ENST00000528419 ENSP00000436568
ENST00000526034 ENSP00000434267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006955 immune response
Cellular Component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E9PI30
UniProt Splice Variant
Entrez Gene 1521
UniGene Hs.416848
RefSeq NM_001335
HUGO HGNC:2546
OMIM 602364
CCDS CCDS8117
HPRD 03840
IMGT
EMBL AP001201
GenPept
RNA Seq Atlas 1521