Version 5.4
Homo sapiens Gene: IL20RB
Summary
InnateDB Gene IDBG-58036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL20RB
Gene Name interleukin 20 receptor beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174564
Encoded Proteins
IDBP-58038
interleukin 20 receptor beta
IDBP-58040
interleukin 20 receptor beta
IDBP-478194
interleukin 20 receptor beta
IDBP-479774
interleukin 20 receptor beta
IDBP-484696
interleukin 20 receptor beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24677051
[Mus musculus] Astrocytes produce IL19 and express IL19 receptors (Il20ra and Il20rb) in response to bacterial pathogens. IL19 can significantly attenuate bacterially induced inflammatory astrocyte responses
Entrez Gene
Summary IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:136946230-137011085
Strand Forward strand
Band q22.3
Transcripts
ENST00000329582 ENSP00000328133
ENST00000309741 ENSP00000311979
ENST00000484501
ENST00000469964 ENSP00000418637
ENST00000491483 ENSP00000417437
ENST00000475972 ENSP00000420725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042015 interleukin-20 binding
Biological Process
GO:0001808 negative regulation of type IV hypersensitivity
GO:0002437 inflammatory response to antigenic stimulus
GO:0002765 immune response-inhibiting signal transduction
GO:0032689 negative regulation of interferon-gamma production
GO:0032703 negative regulation of interleukin-2 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042130 negative regulation of T cell proliferation
GO:0048873 homeostasis of number of cells within a tissue
GO:0050863 regulation of T cell activation
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044244
View Gene Order
ENSBTAG00000008299
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q6UXL0
TrEMBL F8WAV8 F8WC67 H7C5S5
UniProt Splice Variant
Entrez Gene 53833
UniGene Hs.61232
RefSeq NM_144717 XM_006713665
HUGO HGNC:6004
OMIM 605621
CCDS CCDS3093
HPRD
IMGT
EMBL AC011597 AK296832 AK316084 AY358305 BC033292 BC063696 CH471052
GenPept AAH33292 AAH63696 AAQ88672 BAG59402 BAH14455 EAW79101 EAW79104
RNA Seq Atlas 53833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca