InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL6

Summary

InnateDB Gene

IDBG-58050.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL6

Gene Name

ribosomal protein L6

Synonyms

L6; SHUJUN-2; TAXREB107; TXREB1

Species

Homo sapiens

Ensembl Gene

ENSG00000089009

Encoded Proteins

IDBP-58052

ribosomal protein L6

IDBP-383550

ribosomal protein L6

IDBP-594836

ribosomal protein L6

IDBP-594408

ribosomal protein L6

IDBP-586783

ribosomal protein L6

IDBP-588648

ribosomal protein L6

IDBP-598298

ribosomal protein L6

IDBP-811436

ribosomal protein L6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:112405190-112418838

Strand

Reverse strand

Band

q24.13

Transcripts

ENST00000202773	ENSP00000202773
ENST00000424576	ENSP00000403172
ENST00000553205
ENST00000546368
ENST00000550238	ENSP00000448570
ENST00000551041
ENST00000552455
ENST00000549847	ENSP00000446883
ENST00000549562
ENST00000553213	ENSP00000449486
ENST00000551291	ENSP00000448067
ENST00000548343	ENSP00000446859
ENST00000550566	ENSP00000476161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	169 [view]
Protein-Protein	168 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006355	regulation of transcription, DNA-templated
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0036464	cytoplasmic ribonucleoprotein granule