Version 5.4
Homo sapiens Gene: FOXA3
Summary
InnateDB Gene IDBG-58249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXA3
Gene Name forkhead box A3
Synonyms FKHH3; HNF3G; TCF3G
Species Homo sapiens
Ensembl Gene ENSG00000170608
Encoded Proteins
IDBP-58251
forkhead box A3
IDBP-765671
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45863989-45873797
Strand Forward strand
Band q13.32
Transcripts
ENST00000302177 ENSP00000304004
ENST00000594297 ENSP00000470816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001678 cellular glucose homeostasis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0009267 cellular response to starvation
GO:0016568 chromatin modification
GO:0030154 cell differentiation
GO:0031018 endocrine pancreas development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040891
View Gene Order
ENSBTAG00000012104
Not yet available
Pathways
NETPATH
REACTOME
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
hnf3pathway
FOXA transcription factor networks
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.36137
RefSeq NM_004497
HUGO
OMIM
CCDS CCDS12677
HPRD 03802
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca