Version 5.4
Homo sapiens Gene: OAS3
Summary
InnateDB Gene IDBG-58353.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OAS3
Gene Name 2'-5'-oligoadenylate synthetase 3, 100kDa
Synonyms p100
Species Homo sapiens
Ensembl Gene ENSG00000111331
Encoded Proteins
IDBP-58355
2'-5'-oligoadenylate synthetase 3, 100kDa
IDBP-597780
2'-5'-oligoadenylate synthetase 3, 100kDa
IDBP-601226
2'-5'-oligoadenylate synthetase 3, 100kDa
IDBP-602734
2'-5'-oligoadenylate synthetase 3, 100kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21190483
OAS3 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the OAS3 activates RNASEL to cleave ssRNA. The OAS/RNASEL pathway triggers the RIG-I pathway and induce IFNB production.
PMID 26063222
Antiviral activity of the 2â?²,5â?²-oligoadenylate synthetase (OAS) gene variants against dengue virus shows strong and serotype-specific disparities.
InnateDB Annotation from Orthologs
Summary
PMID 21190483
[Mus musculus] Oas3 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas3 activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.
Entrez Gene
Summary This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
This gene encodes an enzyme included in the 2\', 5\' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2\', 5\' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112938352-112973249
Strand Forward strand
Band q24.13
Transcripts
ENST00000228928 ENSP00000228928
ENST00000551007 ENSP00000449299
ENST00000548514 ENSP00000448388
ENST00000546638
ENST00000546800
ENST00000546973 ENSP00000447323
ENST00000549918
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001730 2'-5'-oligoadenylate synthetase activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006955 immune response
GO:0008152 metabolic process
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060700 regulation of ribonuclease activity
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032661
View Gene Order
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.528634 Hs.598232 Hs.737661
RefSeq NM_006187 XM_005253889
HUGO
OMIM
CCDS CCDS44981
HPRD 04519
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca