Homo sapiens Gene: DTX1
Summary
InnateDB Gene IDBG-58410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTX1
Gene Name deltex homolog 1 (Drosophila)
Synonyms hDx-1;
Species Homo sapiens
Ensembl Gene ENSG00000135144
Encoded Proteins
deltex homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:113056709-113098028
Strand Forward strand
Band q24.13
Transcripts
ENST00000257600 ENSP00000257600
ENST00000548759
ENST00000547974
ENST00000553140
ENST00000547730
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0017124 SH3 domain binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007166 cell surface receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008593 regulation of Notch signaling pathway
GO:0010001 glial cell differentiation
GO:0016567 protein ubiquitination
GO:0045581 negative regulation of T cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Notch pathway
TCR pathway
REACTOME
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Disease pathway
KEGG
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Presenilin action in Notch and Wnt signaling
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372152
RefSeq NM_004416
HUGO
OMIM
CCDS CCDS9164
HPRD 03991
IMGT
EMBL
GenPept
RNA Seq Atlas