Homo sapiens Gene: MRPL27
Summary
InnateDB Gene IDBG-58472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL27
Gene Name mitochondrial ribosomal protein L27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108826
Encoded Proteins
mitochondrial ribosomal protein L27
mitochondrial ribosomal protein L27
mitochondrial ribosomal protein L27
mitochondrial ribosomal protein L27
mitochondrial ribosomal protein L27
mitochondrial ribosomal protein L27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50367857-50373214
Strand Reverse strand
Band q21.33
Transcripts
ENST00000225969 ENSP00000225969
ENST00000442592 ENSP00000388915
ENST00000507088 ENSP00000421865
ENST00000508200 ENSP00000424321
ENST00000503633 ENSP00000425126
ENST00000511860 ENSP00000426037
ENST00000514928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 51264
UniGene Hs.711891 Hs.7736
RefSeq NM_016504
HUGO HGNC:14483
OMIM 611837
CCDS CCDS11564
HPRD 14750
IMGT
EMBL
GenPept
RNA Seq Atlas 51264