Version 5.4
Homo sapiens Gene: RBP2
Summary
InnateDB Gene IDBG-58880.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBP2
Gene Name retinol binding protein 2, cellular
Synonyms CRABP-II; CRBP2; CRBPII; RBPC2
Species Homo sapiens
Ensembl Gene ENSG00000114113
Encoded Proteins
IDBP-58882
retinol binding protein 2, cellular
IDBP-483127
retinol binding protein 2, cellular
IDBP-475957
retinol binding protein 2, cellular
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:139452884-139480747
Strand Reverse strand
Band q23
Transcripts
ENST00000232217 ENSP00000232217
ENST00000511956 ENSP00000424333
ENST00000506825 ENSP00000421266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005501 retinoid binding
GO:0016918 retinal binding
GO:0019841 retinol binding
Biological Process
GO:0001523 retinoid metabolic process
GO:0006776 vitamin A metabolic process
GO:0006810 transport
GO:0007603 phototransduction, visible light
GO:0008544 epidermis development
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032454
View Gene Order
ENSBTAG00000015056
Not yet available
Pathways
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
Cross-References
SwissProt
TrEMBL D6RB89 D6RGE6
UniProt Splice Variant
Entrez Gene 5948
UniGene Hs.655516
RefSeq NM_004164 XM_005247693 XM_006713722
HUGO HGNC:9920
OMIM 180280
CCDS CCDS3109
HPRD 07184
IMGT
EMBL AC097103
GenPept
RNA Seq Atlas 5948

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca