Homo sapiens Gene: MRPL11
Summary
InnateDB Gene IDBG-59014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL11
Gene Name mitochondrial ribosomal protein L11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174547
Encoded Proteins
mitochondrial ribosomal protein L11
mitochondrial ribosomal protein L11
mitochondrial ribosomal protein L11
mitochondrial ribosomal protein L11
mitochondrial ribosomal protein L11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66435075-66466738
Strand Reverse strand
Band q13.2
Transcripts
ENST00000310999 ENSP00000308897
ENST00000329819 ENSP00000329630
ENST00000430466 ENSP00000415356
ENST00000524576
ENST00000528272 ENSP00000431405
ENST00000534488 ENSP00000436904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 37 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL E9PQB6
UniProt Splice Variant
Entrez Gene 65003
UniGene Hs.418450 Hs.611590
RefSeq NM_016050 NM_170738 NM_170739 XM_006718666
HUGO HGNC:14042
OMIM 611826
CCDS CCDS44655 CCDS8139 CCDS8140
HPRD 14739
IMGT
EMBL AP002748
GenPept
RNA Seq Atlas 65003