Homo sapiens Gene: ARHGAP35
Summary
InnateDB Gene IDBG-59119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP35
Gene Name Rho GTPase activating protein 35
Synonyms GRF-1; GRLF1; P190-A; P190A; p190ARhoGAP; p190RhoGAP;
Species Homo sapiens
Ensembl Gene ENSG00000160007
Encoded Proteins
Rho GTPase activating protein 35
Rho GTPase activating protein 35
Rho GTPase activating protein 35
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46918676-47005077
Strand Forward strand
Band q13.32
Transcripts
ENST00000404338 ENSP00000385720
ENST00000596593
ENST00000598548
ENST00000595822
ENST00000599284
ENST00000614079 ENSP00000483730
ENST00000615647 ENSP00000479487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005100 Rho GTPase activator activity
GO:0005525 GTP binding
Biological Process
GO:0001843 neural tube closure
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0030900 forebrain development
GO:0032321 positive regulation of Rho GTPase activity
GO:0043010 camera-type eye development
GO:0043116 negative regulation of vascular permeability
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Sema4D mediated inhibition of cell attachment and migration pathway
Semaphorin interactions pathway
Signaling by Rho GTPases pathway
Axon guidance pathway
Signal Transduction pathway
Rho GTPase cycle pathway
KEGG
Focal adhesion pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by focal adhesion kinase
Regulation of RhoA activity
SHP2 signaling
EPHA2 forward signaling
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.509447
RefSeq NM_004491
HUGO
OMIM
CCDS CCDS46127
HPRD 05592
IMGT
EMBL
GenPept
RNA Seq Atlas