InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HK3

Summary

InnateDB Gene

IDBG-59204.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HK3

Gene Name

hexokinase 3 (white cell)

Synonyms

HKIII; HXK3

Species

Homo sapiens

Ensembl Gene

ENSG00000160883

Encoded Proteins

IDBP-59206

hexokinase 3 (white cell)

IDBP-475123

hexokinase 3 (white cell)

IDBP-474260

hexokinase 3 (white cell)

IDBP-478109

hexokinase 3 (white cell)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:176880869-176899332

Strand

Reverse strand

Band

q35.2

Transcripts

ENST00000292432	ENSP00000292432
ENST00000506834
ENST00000514666
ENST00000514058	ENSP00000424632
ENST00000509717	ENSP00000422169
ENST00000504910	ENSP00000427000

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008865	fructokinase activity
GO:0016301	kinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity
GO:0019899	enzyme binding
GO:0042562	hormone binding

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006096	glycolytic process
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0016310	phosphorylation
GO:0019318	hexose metabolic process
GO:0044281	small molecule metabolic process
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process
GO:0055085	transmembrane transport