Homo sapiens Gene: HK3
Summary
InnateDB Gene IDBG-59204.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HK3
Gene Name hexokinase 3 (white cell)
Synonyms HKIII; HXK3;
Species Homo sapiens
Ensembl Gene ENSG00000160883
Encoded Proteins
hexokinase 3 (white cell)
hexokinase 3 (white cell)
hexokinase 3 (white cell)
hexokinase 3 (white cell)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:176880869-176899332
Strand Reverse strand
Band q35.2
Transcripts
ENST00000292432 ENSP00000292432
ENST00000506834
ENST00000514666
ENST00000514058 ENSP00000424632
ENST00000509717 ENSP00000422169
ENST00000504910 ENSP00000427000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019158 mannokinase activity
GO:0019899 enzyme binding
GO:0042562 hormone binding
Biological Process
GO:0001678 cellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0008645 hexose transport
GO:0015758 glucose transport
GO:0016310 phosphorylation
GO:0019318 hexose metabolic process
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Myoclonic epilepsy of Lafora pathway
Glucose transport pathway
Hexose transport pathway
Metabolism of carbohydrates pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Fructose and mannose metabolism pathway
Galactose metabolism pathway
Starch and sucrose metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
Butirosin and neomycin biosynthesis pathway
Insulin signaling pathway pathway
Type II diabetes mellitus pathway
Carbohydrate digestion and absorption pathway
INOH
Fructose Mannose metabolism pathway
Glycolysis Gluconeogenesis pathway
Aminosugars metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P52790
TrEMBL A0A024R7R1 H0Y8U9 H0Y9N6 H0YAG4
UniProt Splice Variant
Entrez Gene 3101
UniGene
RefSeq NM_002115
HUGO HGNC:4925
OMIM 142570
CCDS CCDS4407
HPRD
IMGT
EMBL AC027318 BC028129 CH471195 U42303 U51333
GenPept AAC50422 AAC50732 AAH28129 EAW85048 EAW85049
RNA Seq Atlas 3101