Version 5.4
Homo sapiens Gene: THBD
Summary
InnateDB Gene IDBG-59473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THBD
Gene Name thrombomodulin
Synonyms AHUS6; BDCA3; CD141; THPH12; THRM; TM
Species Homo sapiens
Ensembl Gene ENSG00000178726
Encoded Proteins
IDBP-59475
thrombomodulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:23045633-23049741
Strand Reverse strand
Band p11.21
Transcripts
ENST00000377103 ENSP00000366307
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007596 blood coagulation
GO:0010165 response to X-ray
GO:0010544 negative regulation of platelet activation
GO:0030195 negative regulation of blood coagulation
GO:0032496 response to lipopolysaccharide
GO:0050900 leukocyte migration
GO:0051591 response to cAMP
GO:0051918 negative regulation of fibrinolysis
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074743
View Gene Order
ENSBTAG00000002758
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1439
Common Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Cross-References
SwissProt P07204
TrEMBL
UniProt Splice Variant
Entrez Gene 7056
UniGene Hs.2030
RefSeq NM_000361
HUGO HGNC:11784
OMIM 188040
CCDS CCDS13148
HPRD
IMGT
EMBL AF495471 AL049651 BC035602 BC053357 D00210 J02973 M16552 X05495
GenPept AAA61175 AAB59508 AAH35602 AAH53357 AAM03232 BAA00149 CAA29045 CAB51954
RNA Seq Atlas 7056

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca