Version 5.4
Homo sapiens Gene: PLS1
Summary
InnateDB Gene IDBG-59656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLS1
Gene Name plastin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120756
Encoded Proteins
IDBP-59658
plastin 1
IDBP-384658
plastin 1
IDBP-481845
plastin 1
IDBP-484306
plastin 1
IDBP-477011
plastin 1
IDBP-481330
plastin 1
IDBP-484779
plastin 1
IDBP-475572
plastin 1
IDBP-484925
plastin 1
IDBP-476385
plastin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5\' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:142596387-142713664
Strand Forward strand
Band q23
Transcripts
ENST00000337777 ENSP00000336831
ENST00000457734 ENSP00000387890
ENST00000483373 ENSP00000419893
ENST00000475296 ENSP00000417311
ENST00000495744 ENSP00000419531
ENST00000476044 ENSP00000417481
ENST00000461644 ENSP00000419271
ENST00000464320 ENSP00000418880
ENST00000497199 ENSP00000417491
ENST00000497002 ENSP00000418700
ENST00000460104
ENST00000483507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049493
View Gene Order
ENSBTAG00000023429
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.203637 Hs.707046
RefSeq NM_001145319 NM_001172312 NM_002670 XM_006713660 XM_006713661 XM_006713662
HUGO
OMIM
CCDS CCDS3125
HPRD 04110
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca