Homo sapiens Gene: ATP5S
Summary
InnateDB Gene IDBG-5967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5S
Gene Name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125375
Encoded Proteins
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50312326-50335558
Strand Forward strand
Band q21.3
Transcripts
ENST00000311459 ENSP00000308334
ENST00000245448 ENSP00000245448
ENST00000358473 ENSP00000351258
ENST00000426751 ENSP00000389246
ENST00000554438
ENST00000557421
ENST00000555939
ENST00000554204 ENSP00000451583
ENST00000554951
ENST00000553774
ENST00000556962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015992 proton transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Formation of ATP by chemiosmotic coupling pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.656689
RefSeq NM_001003803 NM_001003805 NM_015684 XM_005267537 XM_005267539
HUGO
OMIM
CCDS CCDS32075 CCDS32076 CCDS45102
HPRD 12503
IMGT
EMBL
GenPept
RNA Seq Atlas