Homo sapiens Gene: MRPL35
Summary
InnateDB Gene IDBG-59750.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL35
Gene Name mitochondrial ribosomal protein L35
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132313
Encoded Proteins
mitochondrial ribosomal protein L35
mitochondrial ribosomal protein L35
mitochondrial ribosomal protein L35
mitochondrial ribosomal protein L35
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:86199355-86213794
Strand Forward strand
Band p11.2
Transcripts
ENST00000337109 ENSP00000338389
ENST00000254644 ENSP00000254644
ENST00000409180 ENSP00000386255
ENST00000605125 ENSP00000473925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL S4R348
UniProt Splice Variant
Entrez Gene 51318
UniGene
RefSeq NM_016622 NM_145644 XM_005264361
HUGO HGNC:14489
OMIM 611841
CCDS CCDS1987 CCDS1988
HPRD
IMGT
EMBL AC009309
GenPept
RNA Seq Atlas 51318