Version 5.4
Homo sapiens Gene: RHOD
Summary
InnateDB Gene IDBG-59813.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOD
Gene Name ras homolog family member D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173156
Encoded Proteins
IDBP-59815
ras homolog gene family, member D
IDBP-594994
ras homolog gene family, member D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67056818-67072013
Strand Forward strand
Band q13.2
Transcripts
ENST00000308831 ENSP00000308576
ENST00000533360
ENST00000532559 ENSP00000432003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0015031 protein transport
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041845
View Gene Order
ENSBTAG00000020600
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.15114
RefSeq NM_001300886 NM_014578 XM_005273963
HUGO
OMIM
CCDS CCDS73330 CCDS8155
HPRD 05776
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca