Version 5.4
Homo sapiens Gene: PLA2G4C
Summary
InnateDB Gene IDBG-59981.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G4C
Gene Name phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms CPLA2-gamma
Species Homo sapiens
Ensembl Gene ENSG00000105499
Encoded Proteins
IDBP-59983
phospholipase A2, group IVC (cytosolic, calcium-independent)
IDBP-761868
IDBP-765954
IDBP-762452
IDBP-763075
IDBP-760949
IDBP-762558
IDBP-761039
IDBP-762193
IDBP-761362
IDBP-759988
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48047843-48110817
Strand Reverse strand
Band q13.33
Transcripts
ENST00000354276 ENSP00000346228
ENST00000597713 ENSP00000473250
ENST00000601946 ENSP00000472977
ENST00000595161 ENSP00000469528
ENST00000594790
ENST00000595899
ENST00000599063
ENST00000599921 ENSP00000469473
ENST00000596352 ENSP00000471759
ENST00000597377
ENST00000598488 ENSP00000468972
ENST00000598457
ENST00000593765
ENST00000594156
ENST00000600170
ENST00000595487 ENSP00000471328
ENST00000598185
ENST00000599111 ENSP00000472546
ENST00000596138 ENSP00000471196
ENST00000596510
ENST00000599300 ENSP00000470418
ENST00000598813
ENST00000599239
ENST00000596353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 2 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0005543 phospholipid binding
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006954 inflammatory response
GO:0007567 parturition
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0019369 arachidonic acid metabolic process
GO:0035556 intracellular signal transduction
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046475 glycerophospholipid catabolic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000033847
View Gene Order
Pathways
NETPATH
REACTOME
REACT_120785
Hydrolysis of LPE pathway
REACT_120829
Acyl chain remodelling of PC pathway
REACT_120722
Acyl chain remodelling of PI pathway
REACT_120977
Hydrolysis of LPC pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa04912
GnRH signaling pathway pathway
hsa00590
Arachidonic acid metabolism pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa04730
Long-term depression pathway
hsa00565
Ether lipid metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001159322 NM_001159323 NM_003706
HUGO
OMIM
CCDS CCDS12710 CCDS54286 CCDS59403
HPRD 04673
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca