Version 5.4
Homo sapiens Gene: CDKL1
Summary
InnateDB Gene IDBG-6007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKL1
Gene Name cyclin-dependent kinase-like 1 (CDC2-related kinase)
Synonyms KKIALRE; P42
Species Homo sapiens
Ensembl Gene ENSG00000100490
Encoded Proteins
IDBP-6009
cyclin-dependent kinase-like 1 (CDC2-related kinase)
IDBP-238737
cyclin-dependent kinase-like 1 (CDC2-related kinase)
IDBP-601728
cyclin-dependent kinase-like 1 (CDC2-related kinase)
IDBP-585612
cyclin-dependent kinase-like 1 (CDC2-related kinase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Alternative splice variants encoding different protein isoforms have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50329592-50416461
Strand Reverse strand
Band q22.1
Transcripts
ENST00000216378 ENSP00000216378
ENST00000356146
ENST00000395834 ENSP00000379176
ENST00000525911 ENSP00000431449
ENST00000534267 ENSP00000435044
ENST00000542671
ENST00000529347
ENST00000528197
ENST00000531052
ENST00000530553
ENST00000534566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007507 heart development
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020990
View Gene Order
ENSBTAG00000004780
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.679430 Hs.708813
RefSeq NM_001282236 NM_004196 XM_005268157
HUGO
OMIM
CCDS CCDS73637 CCDS9699
HPRD 10348
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca