Version 5.4
Homo sapiens Gene: DBN1
Summary
InnateDB Gene IDBG-60129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBN1
Gene Name drebrin 1
Synonyms D0S117E
Species Homo sapiens
Ensembl Gene ENSG00000113758
Encoded Proteins
IDBP-60131
drebrin 1
IDBP-60133
drebrin 1
IDBP-243372
drebrin 1
IDBP-480520
drebrin 1
IDBP-473878
drebrin 1
IDBP-480375
drebrin 1
IDBP-482135
drebrin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer\'s disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177456608-177474401
Strand Reverse strand
Band q35.3
Transcripts
ENST00000309007 ENSP00000308532
ENST00000292385 ENSP00000292385
ENST00000393565 ENSP00000377195
ENST00000472831
ENST00000512501 ENSP00000423208
ENST00000467054
ENST00000477391 ENSP00000422854
ENST00000471767
ENST00000506117 ENSP00000425546
ENST00000514833 ENSP00000421465
ENST00000505550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 86 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005522 profilin binding
Biological Process
GO:0007015 actin filament organization
GO:0007399 nervous system development
GO:0010643 cell communication by chemical coupling
GO:0010644 cell communication by electrical coupling
GO:0032507 maintenance of protein location in cell
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048699 generation of neurons
GO:0050773 regulation of dendrite development
GO:0061351 neural precursor cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005921 gap junction
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030425 dendrite
GO:0042641 actomyosin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034675
View Gene Order
ENSBTAG00000011400
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614285
RefSeq NM_004395 NM_080881 XM_005265827 XM_005265829 XM_006714826
HUGO
OMIM
CCDS CCDS4420 CCDS4421
HPRD 00545
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca