InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FABP1

Summary

InnateDB Gene

IDBG-60424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FABP1

Gene Name

fatty acid binding protein 1, liver

Synonyms

FABPL; L-FABP

Species

Homo sapiens

Ensembl Gene

ENSG00000163586

Encoded Proteins

IDBP-60426

fatty acid binding protein 1, liver

IDBP-242999

fatty acid binding protein 1, liver

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:88122982-88128116

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000295834	ENSP00000295834
ENST00000393750	ENSP00000377351
ENST00000495375
ENST00000472846

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005215	transporter activity
GO:0005324	long-chain fatty acid transporter activity
GO:0005504	fatty acid binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008144	drug binding
GO:0008289	lipid binding
GO:0016209	antioxidant activity
GO:0032052	bile acid binding

Biological Process

GO:0006810	transport
GO:0008284	positive regulation of cell proliferation
GO:0015909	long-chain fatty acid transport
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0050892	intestinal absorption
GO:0051345	positive regulation of hydrolase activity
GO:0070301	cellular response to hydrogen peroxide
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0045179	apical cortex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000054422

View Gene Order

ENSBTAG00000018054

Not yet available

Pathways

NETPATH

REACTOME

REACT_116145

PPARA activates gene expression pathway

REACT_19241

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa03320

PPAR signaling pathway pathway

hsa04975

Fat digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

A8MW49

UniProt Splice Variant

Entrez Gene

2168

UniGene

RefSeq

NM_001443

HUGO

HGNC:3555

OMIM

134650

CCDS

CCDS2001

HPRD

00612

IMGT

EMBL

AC092836

GenPept

RNA Seq Atlas

2168