InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIN2D

Summary

InnateDB Gene

IDBG-60427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIN2D

Gene Name

glutamate receptor, ionotropic, N-methyl D-aspartate 2D

Synonyms

EB11; GluN2D; NMDAR2D; NR2D

Species

Homo sapiens

Ensembl Gene

ENSG00000105464

Encoded Proteins

IDBP-60429

glutamate receptor, ionotropic, N-methyl D-aspartate 2D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48394875-48444931

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000263269

ENSP00000263269

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0001964	startle response
GO:0006810	transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0008344	adult locomotory behavior
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0051930	regulation of sensory perception of pain

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0045202	synapse
GO:0045211	postsynaptic membrane