Version 5.4
Homo sapiens Gene: EIF2AK3
Summary
InnateDB Gene IDBG-60518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2AK3
Gene Name eukaryotic translation initiation factor 2-alpha kinase 3
Synonyms PEK; PERK; WRS
Species Homo sapiens
Ensembl Gene ENSG00000172071
Encoded Proteins
IDBP-60520
eukaryotic translation initiation factor 2-alpha kinase 3
IDBP-382349
eukaryotic translation initiation factor 2-alpha kinase 3
IDBP-382355
eukaryotic translation initiation factor 2-alpha kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:88556741-88627576
Strand Reverse strand
Band p11.2
Transcripts
ENST00000303236 ENSP00000307235
ENST00000419748 ENSP00000408325
ENST00000415570 ENSP00000412076
ENST00000470706
ENST00000478003
ENST00000477083
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0002063 chondrocyte development
GO:0006412 translation
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983 ER overload response
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007029 endoplasmic reticulum organization
GO:0007595 lactation
GO:0009967 positive regulation of signal transduction
GO:0010629 negative regulation of gene expression
GO:0017148 negative regulation of translation
GO:0019217 regulation of fatty acid metabolic process
GO:0019722 calcium-mediated signaling
GO:0030073 insulin secretion
GO:0030282 bone mineralization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0031642 negative regulation of myelination
GO:0032055 negative regulation of translation in response to stress
GO:0032057 negative regulation of translational initiation in response to stress
GO:0032092 positive regulation of protein binding
GO:0032933 SREBP signaling pathway
GO:0034976 response to endoplasmic reticulum stress
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
GO:0045444 fat cell differentiation
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005623 cell
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031668
View Gene Order
ENSBTAG00000000184
Not yet available
Pathways
NETPATH
NetPath_13
IL1 pathway
REACTOME
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591589 Hs.596827
RefSeq NM_004836 XM_005264649
HUGO
OMIM
CCDS CCDS33241
HPRD 04942
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca