Version 5.4
Homo sapiens Gene: RPIA
Summary
InnateDB Gene IDBG-60573.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPIA
Gene Name ribose 5-phosphate isomerase A
Synonyms RPI
Species Homo sapiens
Ensembl Gene ENSG00000153574
Encoded Proteins
IDBP-60575
ribose 5-phosphate isomerase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:88691644-88750935
Strand Forward strand
Band p11.2
Transcripts
ENST00000283646 ENSP00000283646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004751 ribose-5-phosphate isomerase activity
GO:0030246 carbohydrate binding
GO:0048029 monosaccharide binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009052 pentose-phosphate shunt, non-oxidative branch
GO:0019693 ribose phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053604
View Gene Order
ENSBTAG00000002866
Not yet available
Pathways
NETPATH
REACTOME
REACT_1859
Pentose phosphate pathway (hexose monophosphate shunt) pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00030
Pentose phosphate pathway pathway
INOH
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt P49247
TrEMBL Q53R32 Q53SB2
UniProt Splice Variant
Entrez Gene 22934
UniGene Hs.469264 Hs.706053
RefSeq NM_144563
HUGO HGNC:10297
OMIM 180430
CCDS CCDS2004
HPRD
IMGT
EMBL AC062029 AC096579 AY050633 BC015529 L35035
GenPept AAH15529 AAK95569 AAY14778 AAY24200
RNA Seq Atlas 22934

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca