Version 5.4
Homo sapiens Gene: PDGFA
Summary
InnateDB Gene IDBG-6078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFA
Gene Name platelet-derived growth factor alpha polypeptide
Synonyms PDGF-A; PDGF1
Species Homo sapiens
Ensembl Gene ENSG00000197461
Encoded Proteins
IDBP-6080
platelet-derived growth factor alpha polypeptide
IDBP-227495
platelet-derived growth factor alpha polypeptide
IDBP-292444
platelet-derived growth factor alpha polypeptide
IDBP-292445
platelet-derived growth factor alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:497258-520296
Strand Reverse strand
Band p22.3
Transcripts
ENST00000354513 ENSP00000346508
ENST00000400761 ENSP00000383572
ENST00000402802 ENSP00000383889
ENST00000405692 ENSP00000384673
ENST00000426681
ENST00000482462
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001775 cell activation
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002576 platelet degranulation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009611 response to wounding
GO:0009790 embryo development
GO:0009887 organ morphogenesis
GO:0010033 response to organic substance
GO:0010035 response to inorganic substance
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 negative regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910 regulation of smooth muscle cell migration
GO:0030031 cell projection assembly
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032956 regulation of actin cytoskeleton organization
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042493 response to drug
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043588 skin development
GO:0045087 innate immune response
GO:0045740 positive regulation of DNA replication
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048286 lung alveolus development
GO:0048839 inner ear development
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050919 negative chemotaxis
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060683 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005902 microvillus
GO:0009986 cell surface
GO:0016020 membrane
GO:0031093 platelet alpha granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025856
View Gene Order
ENSBTAG00000014541
Not yet available
Pathways
NETPATH
REACTOME
REACT_16888
Signaling by PDGF pathway
REACT_118779
Extracellular matrix organization pathway
REACT_111102
Signal Transduction pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04540
Gap junction pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
GPCR signaling pathway
INOH website
PDGF signaling pathway pathway
PID NCI
ceramide_pathway
Ceramide signaling pathway
pdgf_pathway
PDGF receptor signaling network
Cross-References
SwissProt P04085
TrEMBL Q9UGN0
UniProt Splice Variant
Entrez Gene 5154
UniGene Hs.714993
RefSeq NM_002607 XM_006715733 NM_033023
HUGO HGNC:8799
OMIM 173430
CCDS CCDS34578 CCDS47524
HPRD 01424
IMGT
EMBL AB451309 AB451439 AC147651 AJ238420 M19984 M19985 M19986 M19987 M19988 M19989 M20488 M20489 M20490 M20491 M20492 M20493 M20494 M21571 S62078 X03795 X06374
GenPept AAA60045 AAA60046 AAA60047 AAB26566 BAG70123 BAG70253 CAA27421 CAA29677 CAB59509
RNA Seq Atlas 5154

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca