InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCL19

Summary

InnateDB Gene

IDBG-61011.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL19

Gene Name

chemokine (C-C motif) ligand 19

Synonyms

CKb11; ELC; MIP-3b; MIP3B; SCYA19

Species

Homo sapiens

Ensembl Gene

ENSG00000172724

Encoded Proteins

IDBP-61013

chemokine (C-C motif) ligand 19

IDBP-61015

chemokine (C-C motif) ligand 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:34689567-34691277

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000311925	ENSP00000308815
ENST00000378800	ENSP00000368077
ENST00000485502

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	10 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0031732	CCR7 chemokine receptor binding
GO:0031735	CCR10 chemokine receptor binding
GO:0042379	chemokine receptor binding
GO:0048020	CCR chemokine receptor binding

Biological Process

GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0002407	dendritic cell chemotaxis
GO:0002408	myeloid dendritic cell chemotaxis
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007154	cell communication
GO:0007257	activation of JUN kinase activity
GO:0009615	response to virus
GO:0010560	positive regulation of glycoprotein biosynthetic process
GO:0031295	T cell costimulation
GO:0032320	positive regulation of Ras GTPase activity
GO:0032735	positive regulation of interleukin-12 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034695	response to prostaglandin E
GO:0042102	positive regulation of T cell proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045807	positive regulation of endocytosis
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048469	cell maturation
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050921	positive regulation of chemotaxis
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051897	positive regulation of protein kinase B signaling
GO:0060326	cell chemotaxis
GO:0060491	regulation of cell projection assembly
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071731	response to nitric oxide
GO:0072610	interleukin-12 secretion
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0097029	mature dendritic cell differentiation
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000147	positive regulation of cell motility
GO:2000549	positive regulation of dendritic cell dendrite assembly