Homo sapiens Gene: CCL19
Summary
InnateDB Gene IDBG-61011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL19
Gene Name chemokine (C-C motif) ligand 19
Synonyms CKb11; ELC; MIP-3b; MIP3B; SCYA19;
Species Homo sapiens
Ensembl Gene ENSG00000172724
Encoded Proteins
chemokine (C-C motif) ligand 19
chemokine (C-C motif) ligand 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:34689567-34691277
Strand Reverse strand
Band p13.3
Transcripts
ENST00000311925 ENSP00000308815
ENST00000378800 ENSP00000368077
ENST00000485502
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 10 [view]
Protein-DNA 14 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0031732 CCR7 chemokine receptor binding
GO:0031735 CCR10 chemokine receptor binding
GO:0042379 chemokine receptor binding
GO:0048020 CCR chemokine receptor binding
Biological Process
GO:0001768 establishment of T cell polarity
GO:0001771 immunological synapse formation
GO:0002407 dendritic cell chemotaxis
GO:0002408 myeloid dendritic cell chemotaxis
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007154 cell communication
GO:0007257 activation of JUN kinase activity
GO:0009615 response to virus
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0031295 T cell costimulation
GO:0032320 positive regulation of Ras GTPase activity
GO:0032735 positive regulation of interleukin-12 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034695 response to prostaglandin E
GO:0042102 positive regulation of T cell proliferation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045807 positive regulation of endocytosis
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048469 cell maturation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050921 positive regulation of chemotaxis
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0060491 regulation of cell projection assembly
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071731 response to nitric oxide
GO:0072610 interleukin-12 secretion
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0097029 mature dendritic cell differentiation
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000147 positive regulation of cell motility
GO:2000549 positive regulation of dendritic cell dendrite assembly
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q5VZ75
UniProt Splice Variant
Entrez Gene 6363
UniGene Hs.50002
RefSeq NM_006274
HUGO HGNC:10617
OMIM 602227
CCDS CCDS6570
HPRD 03750
IMGT
EMBL AL162231
GenPept
RNA Seq Atlas 6363