InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCAT2

Summary

InnateDB Gene

IDBG-61179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCAT2

Gene Name

branched chain amino-acid transaminase 2, mitochondrial

Synonyms

BCAM; BCATM; BCT2; PP18

Species

Homo sapiens

Ensembl Gene

ENSG00000105552

Encoded Proteins

IDBP-61181

branched chain amino-acid transaminase 2, mitochondrial

IDBP-294044

branched chain amino-acid transaminase 2, mitochondrial

IDBP-595844

branched chain amino-acid transaminase 2, mitochondrial

IDBP-764192

IDBP-762046

IDBP-761747

IDBP-765863

IDBP-759772

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48795062-48811029

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000316273	ENSP00000322991
ENST00000402551	ENSP00000385161
ENST00000545387	ENSP00000440973
ENST00000598162	ENSP00000470216
ENST00000599246	ENSP00000470680
ENST00000595376
ENST00000601681	ENSP00000472641
ENST00000601496
ENST00000597011	ENSP00000469651
ENST00000593515	ENSP00000469139
ENST00000596981
ENST00000599510

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004084	branched-chain-amino-acid transaminase activity
GO:0052654	L-leucine transaminase activity
GO:0052655	L-valine transaminase activity
GO:0052656	L-isoleucine transaminase activity

Biological Process

GO:0006549	isoleucine metabolic process
GO:0006550	isoleucine catabolic process
GO:0006551	leucine metabolic process
GO:0006573	valine metabolic process
GO:0008152	metabolic process
GO:0009081	branched-chain amino acid metabolic process
GO:0009082	branched-chain amino acid biosynthetic process
GO:0009083	branched-chain amino acid catabolic process
GO:0010817	regulation of hormone levels
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030826

View Gene Order

ENSBTAG00000009172

Not yet available

Pathways

NETPATH

REACTOME

REACT_197

Branched-chain amino acid catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00290

Valine, leucine and isoleucine biosynthesis pathway

hsa00280

Valine, leucine and isoleucine degradation pathway

hsa00770

Pantothenate and CoA biosynthesis pathway

INOH

INOH website

Valine Leucine Isoleucine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.512670

RefSeq

NM_001164773 NM_001190 NM_001284325

HUGO

OMIM

CCDS

CCDS12735 CCDS54290 CCDS74416

HPRD

00217

IMGT

EMBL

GenPept

RNA Seq Atlas