Version 5.4
Homo sapiens Gene: P2RX7
Summary
InnateDB Gene IDBG-61253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX7
Gene Name purinergic receptor P2X, ligand-gated ion channel, 7
Synonyms P2X7
Species Homo sapiens
Ensembl Gene ENSG00000089041
Encoded Proteins
IDBP-61255
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-61257
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-596739
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-589869
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-587658
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-599036
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-588500
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-585487
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-592087
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-600051
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-600433
purinergic receptor P2X, ligand-gated ion channel, 7
IDBP-594902
purinergic receptor P2X, ligand-gated ion channel, 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18765670
P2X7 activity is modulated by human cathelicidin CAMP (LL-37) receptor in a structure-dependent manner and is involved in the proliferative cell response to CAMP.
PMID 21988719
P2RX7 activation in lipopolysaccharide (LPS)-primed myeloid cells results in secretion of pro-inflammatory cytokines IL1B and IL18. In addition, P2RX7 functions in the recognition and phagocytosis of non-opsonized bacteria and apoptotic cells.
PMID 23479230
P2RX7 engagement with ATP analog initiates cutaneous inflammation, dendritic cell differentiation, and induction of Th17 immunity.
PMID 25651887
Stimulation of P2RX7 receptors activates ANO6 to enhance bacterial phagocytosis and killing by macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 21988719
[Mus musculus] P2rx7 activation in lipopolysaccharide (LPS)-primed myeloid cells results in secretion of pro-inflammatory cytokines Il1b and Il18. In addition, P2rx7 functions in the recognition and phagocytosis of non-opsonized bacteria and apoptotic cells. (Demonstrated in human)
Entrez Gene
Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:121132819-121188032
Strand Forward strand
Band q24.31
Transcripts
ENST00000261826 ENSP00000261826
ENST00000328963 ENSP00000330696
ENST00000537312 ENSP00000438586
ENST00000535928 ENSP00000439961
ENST00000539695
ENST00000545434 ENSP00000445564
ENST00000539606 ENSP00000445325
ENST00000541716 ENSP00000437729
ENST00000541022 ENSP00000441230
ENST00000541564 ENSP00000443640
ENST00000538011 ENSP00000439247
ENST00000535600 ENSP00000442470
ENST00000535250 ENSP00000442572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0001530 lipopolysaccharide binding
GO:0001614 purinergic nucleotide receptor activity
GO:0004872 receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005102 receptor binding
GO:0005216 ion channel activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0015267 channel activity
GO:0042803 protein homodimerization activity
GO:0097110 scaffold protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0000902 cell morphogenesis
GO:0001845 phagolysosome assembly
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001934 positive regulation of protein phosphorylation
GO:0002028 regulation of sodium ion transport
GO:0006468 protein phosphorylation
GO:0006509 membrane protein ectodomain proteolysis
GO:0006649 phospholipid transfer to membrane
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006884 cell volume homeostasis
GO:0006900 membrane budding
GO:0006954 inflammatory response
GO:0007005 mitochondrion organization
GO:0007009 plasma membrane organization
GO:0007166 cell surface receptor signaling pathway
GO:0009612 response to mechanical stimulus
GO:0009617 response to bacterium
GO:0010033 response to organic substance
GO:0010043 response to zinc ion
GO:0010467 gene expression
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0012501 programmed cell death
GO:0014049 positive regulation of glutamate secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014070 response to organic cyclic compound
GO:0016079 synaptic vesicle exocytosis
GO:0016485 protein processing
GO:0019228 neuronal action potential
GO:0019233 sensory perception of pain
GO:0019835 cytolysis
GO:0030501 positive regulation of bone mineralization
GO:0031668 cellular response to extracellular stimulus
GO:0032060 bleb assembly
GO:0032308 positive regulation of prostaglandin secretion
GO:0032496 response to lipopolysaccharide
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032963 collagen metabolic process
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0034405 response to fluid shear stress
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042098 T cell proliferation
GO:0042493 response to drug
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043132 NAD transport
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0044254 multicellular organismal protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045332 phospholipid translocation
GO:0045778 positive regulation of ossification
GO:0045779 negative regulation of bone resorption
GO:0045919 positive regulation of cytolysis
GO:0046513 ceramide biosynthetic process
GO:0046931 pore complex assembly
GO:0048705 skeletal system morphogenesis
GO:0048873 homeostasis of number of cells within a tissue
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050717 positive regulation of interleukin-1 alpha secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050830 defense response to Gram-positive bacterium
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051259 protein oligomerization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051592 response to calcium ion
GO:0051602 response to electrical stimulus
GO:0051709 regulation of killing of cells of other organism
GO:0051899 membrane depolarization
GO:0051901 positive regulation of mitochondrial depolarization
GO:0055085 transmembrane transport
GO:0070230 positive regulation of lymphocyte apoptotic process
GO:0072593 reactive oxygen species metabolic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031594 neuromuscular junction
GO:0032059 bleb
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029468
View Gene Order
ENSBTAG00000008948
Not yet available
Pathways
NETPATH
REACTOME
REACT_75808
The NLRP3 inflammasome pathway
REACT_75900
Inflammasomes pathway
REACT_6802
Innate Immune System pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F5H237
UniProt Splice Variant
Entrez Gene 5027
UniGene
RefSeq NM_002562
HUGO HGNC:8537
OMIM 602566
CCDS CCDS9213
HPRD 03977
IMGT
EMBL AC069209 AC079602 Z98941
GenPept
RNA Seq Atlas 5027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca