InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEPT4

Summary

InnateDB Gene

IDBG-61280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPT4

Gene Name

septin 4

Synonyms

ARTS; BRADEION; CE5B3; H5; hCDCREL-2; MART; PNUTL2; SEP4

Species

Homo sapiens

Ensembl Gene

ENSG00000108387

Encoded Proteins

IDBP-61282

septin 4

IDBP-61284

septin 4

IDBP-244334

septin 4

IDBP-382320

septin 4

IDBP-382326

septin 4

IDBP-382334

septin 4

IDBP-761698

IDBP-759286

IDBP-762302

IDBP-761971

IDBP-760390

IDBP-759704

IDBP-758118

IDBP-759635

IDBP-761017

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:58520250-58540818

Strand

Reverse strand

Band

q22

Transcripts

ENST00000317256	ENSP00000321071
ENST00000317268	ENSP00000321674
ENST00000393086	ENSP00000376801
ENST00000457347	ENSP00000402000
ENST00000426861	ENSP00000402348
ENST00000412945	ENSP00000414779
ENST00000582270
ENST00000585170
ENST00000577729	ENSP00000463671
ENST00000580791
ENST00000584528
ENST00000580796
ENST00000580740
ENST00000582248
ENST00000581921
ENST00000580809	ENSP00000464382
ENST00000577440
ENST00000578131	ENSP00000462362
ENST00000579371	ENSP00000464373
ENST00000583291	ENSP00000463461
ENST00000584488
ENST00000580844	ENSP00000462727
ENST00000583114	ENSP00000463768
ENST00000578747
ENST00000583273
ENST00000582976
ENST00000581615	ENSP00000462278
ENST00000584789
ENST00000581607	ENSP00000464360

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0006184	GTP catabolic process
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007286	spermatid development
GO:0007420	brain development
GO:0030382	sperm mitochondrion organization
GO:0031398	positive regulation of protein ubiquitination
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0048240	sperm capacitation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005856	cytoskeleton
GO:0031105	septin complex
GO:0031514	motile cilium
GO:0036126	sperm flagellum
GO:0042995	cell projection
GO:0097227	sperm annulus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020486

View Gene Order

ENSBTAG00000015368

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.711299

RefSeq

NM_001198713 NM_001256782 NM_001256822 NM_004574 NM_080415 NM_080416 XM_006721949 XM_006721951 XM_006721952 XM_006721953 XM_006721954 XM_006721955

HUGO

OMIM

CCDS

CCDS11609 CCDS11610 CCDS45743 CCDS56041 CCDS58581 CCDS58582

HPRD

04738

IMGT

EMBL

GenPept

RNA Seq Atlas