Version 5.4
Homo sapiens Gene: PPP6R3
Summary
InnateDB Gene IDBG-61449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP6R3
Gene Name protein phosphatase 6, regulatory subunit 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110075
Encoded Proteins
IDBP-61451
protein phosphatase 6, regulatory subunit 3
IDBP-61453
protein phosphatase 6, regulatory subunit 3
IDBP-242839
protein phosphatase 6, regulatory subunit 3
IDBP-242841
protein phosphatase 6, regulatory subunit 3
IDBP-587929
protein phosphatase 6, regulatory subunit 3
IDBP-593496
protein phosphatase 6, regulatory subunit 3
IDBP-586607
protein phosphatase 6, regulatory subunit 3
IDBP-597180
protein phosphatase 6, regulatory subunit 3
IDBP-588600
protein phosphatase 6, regulatory subunit 3
IDBP-585908
protein phosphatase 6, regulatory subunit 3
IDBP-588274
protein phosphatase 6, regulatory subunit 3
IDBP-590490
protein phosphatase 6, regulatory subunit 3
IDBP-602931
protein phosphatase 6, regulatory subunit 3
IDBP-600998
protein phosphatase 6, regulatory subunit 3
IDBP-602480
protein phosphatase 6, regulatory subunit 3
IDBP-587220
protein phosphatase 6, regulatory subunit 3
IDBP-603619
protein phosphatase 6, regulatory subunit 3
IDBP-597888
protein phosphatase 6, regulatory subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68460731-68615334
Strand Forward strand
Band q13.2
Transcripts
ENST00000265636 ENSP00000265636
ENST00000265637 ENSP00000265637
ENST00000393801 ENSP00000377390
ENST00000393800 ENSP00000377389
ENST00000530427
ENST00000528635 ENSP00000436789
ENST00000533127 ENSP00000433768
ENST00000529907 ENSP00000431738
ENST00000529344 ENSP00000433551
ENST00000534534 ENSP00000434429
ENST00000524845 ENSP00000431415
ENST00000524904 ENSP00000433058
ENST00000529710 ENSP00000437329
ENST00000527403 ENSP00000433565
ENST00000525050
ENST00000527069
ENST00000531244 ENSP00000432837
ENST00000529172
ENST00000531432
ENST00000534190 ENSP00000436209
ENST00000526574
ENST00000525421 ENSP00000434426
ENST00000526307
ENST00000526593 ENSP00000436601
ENST00000525152
ENST00000530734 ENSP00000433853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0043666 regulation of phosphoprotein phosphatase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024908
View Gene Order
ENSBTAG00000009584
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 55291
UniGene Hs.503022 Hs.624579 Hs.706886
RefSeq NM_001164160 NM_001164161 NM_001164162 NM_001164163 NM_001164164 NM_018312 XM_006718613 XM_006718614 XM_006718616 XM_006718618 XM_006718621 XM_006718624
HUGO HGNC:1173
OMIM 610879
CCDS CCDS53671 CCDS53672 CCDS53673 CCDS53674 CCDS53675 CCDS8182
HPRD 10703
IMGT
EMBL
GenPept
RNA Seq Atlas 55291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca