Homo sapiens Gene: CAMKK2
Summary
InnateDB Gene IDBG-61470.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAMKK2
Gene Name calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms CAMKK; CAMKKB;
Species Homo sapiens
Ensembl Gene ENSG00000110931
Encoded Proteins
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CAMKK2-null macrophages exhibited deficiency to spread, phagocytize bacteria and synthesize cytokines in response to the Toll Like Receptor 4 (TLR4) agonist lipopolysaccharide (LPS). (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Camkk2-null macrophages exhibited deficiency to spread, phagocytize bacteria and synthesize cytokines in response to the Toll Like Receptor 4 (TLR4) agonist lipopolysaccharide (LPS).
Entrez Gene
Summary The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:121237691-121298308
Strand Reverse strand
Band q24.31
Transcripts
ENST00000324774 ENSP00000312741
ENST00000337174 ENSP00000336634
ENST00000347034 ENSP00000321230
ENST00000392474 ENSP00000376266
ENST00000392473 ENSP00000376265
ENST00000402834 ENSP00000384591
ENST00000404169 ENSP00000384600
ENST00000446440 ENSP00000388273
ENST00000412367 ENSP00000388368
ENST00000538733 ENSP00000445944
ENST00000545538 ENSP00000441352
ENST00000535524
ENST00000542540
ENST00000539380
ENST00000543477 ENSP00000444894
ENST00000544485 ENSP00000445400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0045859 regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
Regulation of pgc-1a [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Ca-calmodulin-dependent protein kinase activation [Biocarta view]
PID NCI
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt
TrEMBL F5H360 Q8IZW1
UniProt Splice Variant
Entrez Gene 10645
UniGene Hs.297343 Hs.621928
RefSeq NM_001270485 NM_001270486 NM_006549 NM_153499 NM_153500 NM_172214 NM_172215 NM_172216 NM_172226 XM_005253822 XM_005253823 XM_005253824
HUGO HGNC:1470
OMIM 615002
CCDS CCDS44999 CCDS53837 CCDS58283 CCDS9216 CCDS9217 CCDS9218 CCDS9219
HPRD 06467
IMGT
EMBL AC069209 AF425668
GenPept AAN37388
RNA Seq Atlas 10645