Version 5.4
Homo sapiens Gene: PAK6
Summary
InnateDB Gene IDBG-6170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK6
Gene Name p21 protein (Cdc42/Rac)-activated kinase 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137843
Encoded Proteins
IDBP-6172
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-365817
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-365819
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-365820
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-584999
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-589747
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-592692
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-588314
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-585454
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-584733
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-586004
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-590568
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-589192
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-599550
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-585526
p21 protein (Cdc42/Rac)-activated kinase 6
IDBP-600572
p21 protein (Cdc42/Rac)-activated kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40238759-40277487
Strand Forward strand
Band q15.1
Transcripts
ENST00000260404 ENSP00000260404
ENST00000441369 ENSP00000406873
ENST00000453867 ENSP00000401153
ENST00000455577 ENSP00000409465
ENST00000561230 ENSP00000453520
ENST00000558055 ENSP00000453407
ENST00000560346 ENSP00000453858
ENST00000558878 ENSP00000452737
ENST00000558183 ENSP00000452647
ENST00000560806 ENSP00000453005
ENST00000558106 ENSP00000453721
ENST00000559617 ENSP00000452708
ENST00000560684 ENSP00000453057
ENST00000559139 ENSP00000452686
ENST00000560669 ENSP00000453021
ENST00000542403 ENSP00000439597
ENST00000559901
ENST00000557926
ENST00000557808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007010 cytoskeleton organization
GO:0023014 signal transduction by phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074923
View Gene Order
ENSBTAG00000019076
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04360
Axon guidance pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL H0YKB6 H0YL02 H0YL47
UniProt Splice Variant
Entrez Gene 56924
UniGene Hs.513645 Hs.732375
RefSeq NM_001276717 NM_001276718 NM_020168 NM_001128628 NM_001128629
HUGO HGNC:16061
OMIM 608110
CCDS CCDS10054 CCDS61590
HPRD 06426
IMGT
EMBL AC020658 AC025429
GenPept
RNA Seq Atlas 56924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca