Homo sapiens Gene: ELK1
Summary
InnateDB Gene IDBG-61826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELK1
Gene Name ELK1, member of ETS oncogene family
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000126767
Encoded Proteins
ELK1, member of ETS oncogene family
ELK1, member of ETS oncogene family
ELK1, member of ETS oncogene family
ELK1, member of ETS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47635521-47650604
Strand Reverse strand
Band p11.23
Transcripts
ENST00000247161 ENSP00000247161
ENST00000376983 ENSP00000366182
ENST00000343894 ENSP00000345585
ENST00000480157
ENST00000468956
ENST00000592066 ENSP00000467055
ENST00000619324 ENSP00000483056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 50 [view]
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0009416 response to light stimulus
GO:0030154 cell differentiation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0071394 cellular response to testosterone stimulus
GO:0071396 cellular response to lipid
GO:0071480 cellular response to gamma radiation
GO:1901216 positive regulation of neuron death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
ID pathway
KitReceptor pathway
BCR pathway
IL2 pathway
IL4 pathway
IL5 pathway
Leptin pathway
Prolactin pathway
REACTOME
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
NGF signalling via TRKA from the plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
ERK/MAPK targets pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Focal adhesion pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Prion diseases pathway
Leishmaniasis pathway
Endometrial cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Toll-like receptor pathway [Biocarta view]
Signaling pathway from g-protein families [Biocarta view]
Bcr signaling pathway [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Pdgf signaling pathway [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Tpo signaling pathway [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na´ve CD8+ T cells
S1P2 pathway
ErbB1 downstream signaling
HIF-2-alpha transcription factor network
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Ras signaling in the CD4+ TCR pathway
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001114123 NM_001257168 NM_005229
HUGO
OMIM
CCDS CCDS14283 CCDS59165
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas